109 Savage Hall
Nutri. Sciences, Cornell University
Ithaca, NY 14853
- EMAIL: BJS13@CORNELL.EDU
- PHONE: 607-255-2694
- FAX: 607-255-1033
Barbara J. Strupp
Adjunct Professor of Psychology and Professor of Nutritional Sciences
In my lab, we are using rodent models to study human developmental cognitive disorders. This research is designed to identify the specific cognitive and affective processes that are affected and link these with underlying neural changes. The ultimate goals are to improve therapeutic intervention and elucidate basic brain-cognition relationships. Two projects, concerning prenatal cocaine exposure and early lead exposure, utilize rat models, whereas three other projects involve genetically manipulated mouse models of human disorders. These three projects deal with, respectively, mouse models of Down syndrome (the Ts65Dn mouse, which has a partial trisomy of chromosome 16),Fragile X syndrome (the fmr1 "knockout" mouse), and mice with a mutation in an enzyme involved in folate metabolism, to further investigate the role of folate alterations in neurogenesis and aging-related cognitive decline. We have recently discovered that perinatal supplementation with excess choline results in lasting cognitive benefits in the Down syndrome (DS) mouse model. This finding suggests that perinatal choline supplementation might significantly reduce the cognitive dysfunction seen in DS as well as reduce the risk of Alzheimer's Disease and age-related cognitive decline in the population at large. We are currently investigating the neural bases of this striking benefit.
Elsewhere on the Web
Beaudin S, Stangle DE, Strawderman M, Levitsky, DA, and Strupp BJ. (2007) Succimer chelation normalizes emotion regulation in rats exposed to lead early in life: Evidence from an olfactory conditional discrimination task with periodic omission of an expected reward. Neurotox. Teratol 2007, 29: 188–202 [Online 12 November 2006].